Ic50 graphpad prism 51/8/2023 ![]() Cell lines that are more resistant tend to have a shallow slope. (B) Cell lines differ in their position (x-axis) and slope (y-axis) parameter. ![]() (A) The population dose–response estimated by the model from the data. Graphical presentation of the model parameters. The inset (AUC) illustrates the area under the curve in the screening range, and is defined as A/(A + B).ĪUC: Area under the curve. Examples of a less potent drug (II) and a more potent drug (III) are shown with dashed lines. Changes to the center of the function define the change in IC 50, which is the concentration at which the relative viability is 0.5 (horizontal line). Each series spans 256-fold concentration range, and each unit translates to a twofold difference, meaning that 7 to 9 translates to a fourfold difference. ![]() Sigmoid dose–response relation for a mock compound.īlack line (I) shows the dose response function with a linear phase in the center of the sigmoid. First draft submitted: 6 October 2015 Accepted for publication: 2 February 2016 Published online: Figure 1.
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